Sam and Dean get themselves admitted to a mental hospital in order to investigate if a monster is attacking patients. But their incarceration pushes them to the breaking point.
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Teenagers decide to collect on the bounty on Dean's head by one of them switching bodies with Sam. While Sam has to deal with domineering parents and high school, Dean discovers Sam has a new enthusiasm for the monster-hunting profession.
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Anna travels in time to kill Mary and John before they can conceive Sam and Dean, preventing the apocalypse. Castiel transports the brothers to save their parents but they must answer questions when their parents wonder what's going on.
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Sam and Dean investigate when several police officers seem to have been killed by the biblical plagues of Eqypt. Castiel joins in the probe and reveals there is chaos in heaven and that some of its weapons were stolen.
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Dean is turned into a vampire after he is bitten while investigating the disappearance of some girls from a small town. Sam and Dean learn that the town is overrun with vampires.
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Sam and Dean investigate a series of suicides in which the victims were told brutal truths that drove them to violence. Their probe reveals the Goddess of Truth, Veritas, is responsible and that their next target is Dean.
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Dean is abducted from a crop circle while investigating a UFO sighting. He quickly discovers he isn't dealing with aliens but rather with fairies. Sam searches for him and stumbles upon a world occupied by elves, gnomes, and a leprechaun.
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Meg kidnaps Sam & Dean to force them to reveal Crowley's hideout. They promise to help her if she will torture Crowley to gain information about how Sam can get his soul back.
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